

For US residents only
What is ORKAMBI?
Talk to your doctor before taking ORKAMBI if you take any of the medicines or supplements listed above.
ORKAMBI® (lumacaftor/ivacaftor) is a prescription medicine used for the treatment of cystic fibrosis (CF) in patients age 2 years and older who have two copies of the F508del mutation (F508del/F508del) in their CFTR gene.
ORKAMBI should not be used in patients other than those who have two copies of the F508del mutation in their CFTR gene.
It is not known if ORKAMBI is safe and effective in children under 2 years of age.
Important safety information
ORKAMBI is a prescription medicine used for the treatment of cystic fibrosis (CF) in patients age 2 years and older who have two copies of the F508del mutation (F508del/F508del) in their CFTR gene.
ORKAMBI should not be used in patients other than those who have two copies of the F508del mutation in their CFTR gene.
It is not known if ORKAMBI is safe and effective in children under 2 years of age.
People with CF pictured may or may not be taking ORKAMBI.
Talk to your doctor before taking ORKAMBI if you take any of the medicines or supplements listed above.
Tell your doctor about all the medicines you take, including prescription and over-the-counter medicines, vitamins, and herbal supplements, because the dose of ORKAMBI may need to be adjusted when taken with certain medicines.
Especially tell your doctor if you take:
Tell your doctor if you stop ORKAMBI for more than 1 week. Your doctor may need to change your dose of ORKAMBI or other medicines you take.
ORKAMBI can cause serious side effects, including:
Call your doctor right away if you have any of the following symptoms of liver problems:
The most common side effects of ORKAMBI include:
Side effects seen in children are similar to those seen in adults and adolescents. Additional common side effects seen in children include:
These are not all the possible side effects of ORKAMBI. Call your doctor for medical advice about side effects. You are encouraged to report side effects to FDA at 1-800-FDA-1088.
For further information, please see full Prescribing Information, including Patient Information.
People with CF pictured may or may not be taking ORKAMBI.
Talk to your doctor before taking ORKAMBI if you take any of the medicines or supplements listed above.
Tell your doctor about all the medicines you take, including prescription and over-the-counter medicines, vitamins, and herbal supplements, because the dose of ORKAMBI may need to be adjusted when taken with certain medicines.
Especially tell your doctor if you take:
Tell your doctor if you stop ORKAMBI for more than 1 week. Your doctor may need to change your dose of ORKAMBI or other medicines you take.
ORKAMBI can cause serious side effects, including:
Call your doctor right away if you have any of the following symptoms of liver problems:
The most common side effects of ORKAMBI include:
Side effects seen in children are similar to those seen in adults and adolescents. Additional common side effects seen in children include:
These are not all the possible side effects of ORKAMBI. Call your doctor for medical advice about side effects. You are encouraged to report side effects to FDA at 1-800-FDA-1088.
For further information, please see full Prescribing Information, including Patient Information.
People with CF pictured may or may not be taking ORKAMBI.
Tell your doctor about all the medicines you take, including prescription and over-the-counter medicines, vitamins, and herbal supplements, because the dose of ORKAMBI may need to be adjusted when taken with certain medicines.
Especially tell your doctor if you take:
Tell your doctor if you stop ORKAMBI for more than 1 week. Your doctor may need to change your dose of ORKAMBI or other medicines you take.
ORKAMBI can cause serious side effects, including:
Call your doctor right away if you have any of the following symptoms of liver problems:
The most common side effects of ORKAMBI include:
Side effects seen in children are similar to those seen in adults and adolescents. Additional common side effects seen in children include:
These are not all the possible side effects of ORKAMBI. Call your doctor for medical advice about side effects. You are encouraged to report side effects to FDA at 1-800-FDA-1088.
For further information, please see full Prescribing Information, including Patient Information.
People with CF pictured may or may not be taking ORKAMBI.
What is ORKAMBI?
Talk to your doctor before taking ORKAMBI if you take any of the medicines or supplements listed above.
ORKAMBI® (lumacaftor/ivacaftor) is a prescription medicine used for the treatment of cystic fibrosis (CF) in patients age 2 years and older who have two copies of the F508del mutation (F508del/F508del) in their CFTR gene.
ORKAMBI should not be used in patients other than those who have two copies of the F508del mutation in their CFTR gene.
It is not known if ORKAMBI is safe and effective in children under 2 years of age.
Important safety information
ORKAMBI is a prescription medicine used for the treatment of cystic fibrosis (CF) in patients age 2 years and older who have two copies of the F508del mutation (F508del/F508del) in their CFTR gene.
ORKAMBI should not be used in patients other than those who have two copies of the F508del mutation in their CFTR gene.
It is not known if ORKAMBI is safe and effective in children under 2 years of age.
People with CF pictured may or may not be taking ORKAMBI.
Talk to your doctor before taking ORKAMBI if you take any of the medicines or supplements listed above.
Tell your doctor about all the medicines you take, including prescription and over-the-counter medicines, vitamins, and herbal supplements, because the dose of ORKAMBI may need to be adjusted when taken with certain medicines.
Especially tell your doctor if you take:
Tell your doctor if you stop ORKAMBI for more than 1 week. Your doctor may need to change your dose of ORKAMBI or other medicines you take.
ORKAMBI can cause serious side effects, including:
Call your doctor right away if you have any of the following symptoms of liver problems:
The most common side effects of ORKAMBI include:
Side effects seen in children are similar to those seen in adults and adolescents. Additional common side effects seen in children include:
These are not all the possible side effects of ORKAMBI. Call your doctor for medical advice about side effects. You are encouraged to report side effects to FDA at 1-800-FDA-1088.
For further information, please see full Prescribing Information, including Patient Information.
People with CF pictured may or may not be taking ORKAMBI.
Talk to your doctor before taking ORKAMBI if you take any of the medicines or supplements listed above.
Tell your doctor about all the medicines you take, including prescription and over-the-counter medicines, vitamins, and herbal supplements, because the dose of ORKAMBI may need to be adjusted when taken with certain medicines.
Especially tell your doctor if you take:
Tell your doctor if you stop ORKAMBI for more than 1 week. Your doctor may need to change your dose of ORKAMBI or other medicines you take.
ORKAMBI can cause serious side effects, including:
Call your doctor right away if you have any of the following symptoms of liver problems:
The most common side effects of ORKAMBI include:
Side effects seen in children are similar to those seen in adults and adolescents. Additional common side effects seen in children include:
These are not all the possible side effects of ORKAMBI. Call your doctor for medical advice about side effects. You are encouraged to report side effects to FDA at 1-800-FDA-1088.
For further information, please see full Prescribing Information, including Patient Information.
People with CF pictured may or may not be taking ORKAMBI.
Tell your doctor about all the medicines you take, including prescription and over-the-counter medicines, vitamins, and herbal supplements, because the dose of ORKAMBI may need to be adjusted when taken with certain medicines.
Especially tell your doctor if you take:
Tell your doctor if you stop ORKAMBI for more than 1 week. Your doctor may need to change your dose of ORKAMBI or other medicines you take.
ORKAMBI can cause serious side effects, including:
Call your doctor right away if you have any of the following symptoms of liver problems:
The most common side effects of ORKAMBI include:
Side effects seen in children are similar to those seen in adults and adolescents. Additional common side effects seen in children include:
These are not all the possible side effects of ORKAMBI. Call your doctor for medical advice about side effects. You are encouraged to report side effects to FDA at 1-800-FDA-1088.
For further information, please see full Prescribing Information, including Patient Information.
People with CF pictured may or may not be taking ORKAMBI.