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People with CF pictured may 
or may not be taking ORKAMBI.

How to take ORKAMBI®

Take ORKAMBI every 12 hours as directed

clock-green@2x.pngYour healthcare provider will tell you exactly how much ORKAMBI you or your child should take and when it should be taken.

 

A fat-containing meal or snack helps the body better absorb the medicine. ORKAMBI should always be taken before or after a meal or snack that contains fat. Get recipes for fat-containing meals and snacks.

 

grapefruit_icon@2x.pngAvoid foods and drinks that contain grapefruit during your child's first week taking ORKAMBI because they can increase the amount of ORKAMBI in their body.

 

How to Take ORKAMBI 
Oral Granules (Children 
Age 1 Through 5 Years)

How to Take ORKAMBI 
Tablets (People Age 6 
Years and Older)

FAQs

Select a button below for information and tips on giving your child ORKAMBI granules.

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What to take when

Designed with a young child in mind

ORKAMBI comes in single-use, oral granule packets for children age 1 through 5 years with cystic fibrosis (CF). The oral granules are similar in size to flour particles and should be mixed with 1 teaspoon (5 mL) of soft food or liquid.

 

Dosage strengths for ORKAMBI oral granules

ORKAMBI oral granules are prescribed based on weight and come in 3 different strengths.

AGE 1 THROUGH 2 YEARS OLD
WEIGHT-BASED DOSE
15 lbs to less than 20 lbs
(7 kg to less than 9 kg)

lumacaftor 75 mg/ivacaftor 94 mg
20 lbs to less than 31 lbs
(9 kg to less than 14 kg)

lumacaftor 100 mg/ivacaftor 125 mg
31 lbs or more (14 kg or more)
lumacaftor 150 mg/ivacaftor 188 mg
Recommended Dose
1 packet every 12 hours
(2 packets per day)
AGE WEIGHT-BASED DOSE RECOMMENDED DOSE
1 through 2 years old
15 lbs to less than 20 lbs (7 kg to less than 9 kg)
lumacaftor 75 mg/ivacaftor 94 mg
1 packet every 12 hours
(2 packets per day)
20 lbs to less than 31 lbs (9 kg to less than 14 kg)
lumacaftor 100 mg/ivacaftor 125 mg
31 lbs or more (14 kg or more)
lumacaftor 150 mg/ivacaftor 188 mg
2 through 5 years old
Less than 31 lbs (less than 14 kg)
lumacaftor 100 mg/ivacaftor 125 mg
31 lbs or more (14 kg or more)
lumacaftor 150 mg/ivacaftor 188 mg

 

AGE 2 THROUGH 5 YEARS OLD
WEIGHT-BASED DOSE
Less than 31 lbs (less than 14 kg) lumacaftor 100 mg/ivacaftor 125 mg
31 lbs or more (14 kg or more) lumacaftor 150 mg/ivacaftor 188 mg
Recommended Dose
1 packet every 12 hours
(2 packets per day)

 

 

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Your child should take ORKAMBI, plus all of your child's other CF therapies, exactly as your child's healthcare provider says they should be taken. 

How ORKAMBI oral granules are packaged

Every carton of ORKAMBI has 56 ORKAMBI oral granule packets, organized in 4 weekly wallets. Each wallet has 2 packets for each of the 7 days in a week.

ORKAMBI oral granules for children age 1 through 2 years weighing 15 lbs to less than 20 lbs (7 kg to less than 9 kg)

For children age 1 through 2 years
weighing 15 lbs to less than 20 lbs
 (7 kg to less than 9 kg)

ORKAMBI oral granules for children age 1 through 2 years weighing 20 lbs to less than 31 lbs (9 kg to less than 14 kg) and children age 2 through 5 years weighing less than 31 lbs (less than 14 kg)

For children age 1 through 2 years weighing
20 lbs to less than 31 lbs (9 kg to less than 14 kg)

and children age 2 through 5 years
weighing less than 31 lbs (less than 14 kg)

ORKAMBI oral granules for children age 1 through 2 years weighing 31 lbs or more (14 kg or more) and children age 2 through 5 years weighing 31 lbs or more (14 kg or more)

For children age 1 through 2 years
weighing 31 lbs or more (14 kg or more)

and children age 2 through 5 years
weighing 31 lbs or more (14 kg or more)

What if your child misses a dose of ORKAMBI?

  • If your child misses a dose of ORKAMBI and it is within 6 hours of when they usually take it, have your child take the dose of ORKAMBI as prescribed with fat-containing food as soon as possible
  • If your child misses a dose and it is more than 6 hours after the time they usually take it, have your child skip that dose only and take the next dose with fat-containing food when they usually take it. Do not take 2 doses at the same time to make up for a missed dose
  • Tell your child’s healthcare provider if your child stops taking ORKAMBI for more than 1 week. The healthcare provider may need to change your child’s ORKAMBI dose or other medicines your child takes

How to give your child ORKAMBI oral granules

preparation imageSTEP 1: Preparation
  • Hold the packet with the cut line on top
  • Shake the packet gently to settle the ORKAMBI granules
  • Tear or cut packet open along cut line
  • Carefully pour all of the ORKAMBI granules in the packet into 1 teaspoon (5 mL) of soft food such as flavored pudding or yogurt, or liquid such as juice, in a small container. Food or liquid should be at or below room temperature
  • Here are examples of foods and liquids you can mix ORKAMBI granules into. Remember, every child is different, so be sure to talk to your healthcare provider about what the best options are for your child
    • Breast milk
    • Infant formula
    • Puréed fruit or vegetables
    • Yogurt or pudding (flavored if desired)
    • Applesauce
    • Water
    • Milk
    • Juice
  • Then, mix the granules with the 1 teaspoon of food or liquid

 

STEP 2: Administration
  • Within 1 hour of mixing, give ORKAMBI to your child
  • Make sure the entire medicine mixture is taken

 

STEP 3: Fat-containing food before or after dose

Always take ORKAMBI with fat-containing food

  • Make sure to always give your child food that contains fat just before or after the dose of ORKAMBI oral granules. This helps the body absorb ORKAMBI better

Here are suggestions for fat-containing foods to give your child:

  • Breast milk
  • Infant formula
  • Whole milk
  • Whole-milk yogurt
  • Eggs
  • Whole-milk cheese
  • Butter
  • Peanut butter
  • Cheese pizza
  • Avocados
  • Nuts
     

Tips for helping your child take ORKAMBI oral granules

Your child may find that ORKAMBI oral granules have a bitter taste. Every dose matters, so it's important to make sure your child completely finishes the ORKAMBI mixture at each dose. Here are a few tips that may help.

Chocolate pudding

Mix the granules with 1 teaspoon
(5 mL) of soft food or liquid
that is sweet or rich, like pudding, chocolate sauce, caramel sauce, or melted ice cream.

Honey

Give your child something sweet, like maple syrup or honey, after they completely finish the dose. It may help with the aftertaste.

Ice pop

Numb the taste buds before taking ORKAMBI by having your child eat an ice pop or another cold treat before each dose.

Pizza

Put some control in your child’s hands by letting them choose a favorite fat-containing food to eat before or after taking ORKAMBI.

Teddy bear icon

Does your child have a favorite doll or toy? Holding a special toy while taking ORKAMBI may make your child feel more comfortable.

Sticker icon

Try creating a rewards system for finishing ORKAMBI, such as collecting stickers. You know best how to keep your child motivated!

Image of child with parent

Dosage strengths for ORKAMBI tablets

AGE EACH TABLET EACH DOSE TOTAL DAILY DOSE
Children age 6 
through 11 years
Lumacaftor 100 mg/
ivacaftor 125 mg 
2 tablets
every 12 hours
4 tablets
per day
People age 12 years 
and older
Lumacaftor 200 mg/
ivacaftor 125 mg 
2 tablets
every 12 hours
4 tablets
per day
AGE
Children age 6 through 11 years
EACH TABLET
Lumacaftor 100 mg/
ivacaftor 125 mg
EACH DOSE
2 tablets
every 12 hours
TOTAL DAILY DOSE
4 tablets
per day

 

AGE
People age 12 years
and older
EACH TABLET
Lumacaftor 200 mg/
ivacaftor 125 mg
EACH DOSE
2 tablets
every 12 hours
TOTAL DAILY DOSE
4 tablets
per day

 

How ORKAMBI tablets are packaged

Each carton of ORKAMBI has 4 weekly wallets. Inside each weekly wallet are 7 daily blister strips. Every blister strip contains 4 tablets: 2 for the morning, and 12 hours later, 2 for the evening. When taking ORKAMBI, remove 2 tablets from the blister strip (do not push tablet through backing).

You can cut along the blister strip’s dotted line to separate your or your child’s morning and evening doses, which contain the same amount of medicine.

ORKAMBI tablet packaging

What if you or your child misses a dose of ORKAMBI?

  • If you or your child misses a dose of ORKAMBI and it is within 6 hours of when it's usually taken, you or your child should take the dose as prescribed with fat-containing food as soon as possible
  • If you or your child misses a dose and it is more than 6 hours after the time it's usually taken, you or your child should skip that dose only and take the next dose with fat-containing food at the usual time. Do not take 2 doses at the same time to make up for a missed dose
  • Tell your healthcare provider if you or your child stops taking ORKAMBI for more than 1 week. Your healthcare provider may need to change the ORKAMBI dose or other medicines

If I mix the ORKAMBI oral granules with a fat-containing food, do I still need to give my child fat-containing food afterwards?


Yes, your child should still eat fat-containing food just before or just after taking the entire mixture.

 

Does the temperature of the food that I mix with ORKAMBI oral granules matter? Can the granules be mixed in foods that are hot or cold?


The granules should be mixed with soft food or liquid at room temperature or below. The granules should not be mixed in items that are frozen or hot.

 

Can my child swallow the granules without mixing them in soft food or liquid?


The entire contents of each packet should be mixed with 1 teaspoon (5 mL) of age-appropriate soft food or liquid. The mixture should be taken within 1 hour of being mixed. Make sure all medicine is taken.

 

My child vomited after taking the dose of ORKAMBI oral granules. What should I do?


You should contact your child’s healthcare provider to discuss this. Your pharmacist may also be a good resource.

 

If my child is napping when it is time for ORKAMBI oral granules, should I wait until they’re awake to administer them?


You should give your child ORKAMBI oral granules every 12 hours or as prescribed by your child’s healthcare provider.

 

What can I do if my child doesn't like the taste of ORKAMBI granules?


It's important to make sure your child completely finishes the ORKAMBI mixture at each dose. If they don’t like the taste, there are a few tips that may help.

Start by mixing the granules into a food that is sweet or rich, like pudding, chocolate sauce, caramel sauce, or melted ice cream. You can also try giving your child something sweet, like maple syrup or honey, after the dose. Giving your child an ice pop or cold treat before they take ORKAMBI may help by numbing their taste buds.

For a different approach, put some control in your child’s hands by letting them choose a favorite fat-containing food to eat before or after taking ORKAMBI. Letting your child hold a special toy while taking ORKAMBI may make them feel more comfortable. You could also try creating a rewards system for finishing ORKAMBI, such as collecting stickers or something else that motivates your child.

 

How are ORKAMBI oral granules packaged?


Every carton has 56 ORKAMBI oral granule packets, organized in 4 weekly wallets. Each wallet has 2 packets for each of the 7 days in a week.

 

Are the oral granules packets child proof?


The packets are child-resistant.

 

How should ORKAMBI oral granules and tablets be stored?


ORKAMBI should be stored at 68°F to 77°F (20°C to 25°C). Do not use ORKAMBI after the expiration date on the package. Keep ORKAMBI and all medicines out of the reach of children.

 

How are ORKAMBI tablets packaged?


Each carton of ORKAMBI has 4 weekly wallets. Inside each weekly wallet are 7 daily blister strips. Every blister strip contains 4 tablets: 2 for the morning, and 12 hours later, 2 for the evening.

 

Can I separate the doses on the blister cards?


You may cut along the dotted line to separate your doses from the blister card.

 

My child is over 6 years old and has trouble swallowing pills. Can my child take oral granules?


ORKAMBI oral granules are for patients age 1 through 5 years old. ORKAMBI tablets are for people age 6 years and older.

 

What should my child avoid while taking ORKAMBI?


Avoid foods and drinks that contain grapefruit during your child's first week taking ORKAMBI because they can increase the amount of ORKAMBI in their body.