Before Starting ORKAMBI®

Before starting ORKAMBI, there are some important things you should discuss with your doctor, including your medical history and the medicines you take.

Who should not take ORKAMBI?

Do not take ORKAMBI if you take certain medicines or herbal supplements, such as:

  • antibiotics: rifampin (Rifamate®, Rifater®) or rifabutin (Mycobutin®)
  • seizure medicines: phenobarbital, carbamazepine (Tegretol®, Carbatrol®, and Equetro®), or phenytoin (Dilantin®, Phenytek®)
  • sedatives/anti-anxiety medicines: triazolam (Halcion®) or midazolam (Dormicum®, Hypnovel®, and Versed®)
  • immunosuppressant medicines: everolimus (Zortress®), sirolimus (Rapamune®), or tacrolimus (Astagraf XL®, Envarsus XR®, Prograf®, and Protopic®)
  • St. John’s wort (Hypericum perforatum)

Talk to your doctor before taking ORKAMBI if you take any of the medicines or supplements listed above.

Before you take ORKAMBI, tell your doctor if you:

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Have or have had liver problems

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Have had an organ transplant

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Have kidney problems

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Are using birth control (hormonal contraceptives including oral, injectable, transdermal, or implantable forms). Hormonal contraceptives should not be used as a method of birth control when taking ORKAMBI. Talk to your doctor about the best birth-control method you should use while taking ORKAMBI

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Are pregnant or plan to become pregnant. It is not known if ORKAMBI will harm your unborn baby. You and your doctor should decide if you will take ORKAMBI while you are pregnant

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Are breastfeeding or planning to breastfeed. It is not known if ORKAMBI passes into your breast milk. You and your doctor should decide if you will take ORKAMBI while you are breastfeeding

ORKAMBI and other medicines

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ORKAMBI may affect the way other medicines work, and other medicines may affect how ORKAMBI works. Tell your doctor about all the medicines you take, including prescription and over-the-counter medicines, vitamins, and herbal supplements, because the dose of ORKAMBI may need to be adjusted when taken with certain medicines. Ask your doctor or pharmacist for a list of these medicines if you are not sure.

Especially tell your doctor if you take:

Antifungal medicines, such as:
  • Ketoconazole (eg, Nizoral®)
  • Itraconazole (eg, Sporanox®)
  • Posaconazole (eg, Noxafil®)
  • Voriconazole (eg, Vfend®)
Antibiotics, such as:
  • Telithromycin (eg, Ketek®)
  • Clarithromycin (eg, Biaxin®)
  • Erythromycin (eg, Ery-Tab®)

Remember, it is important to know the medicines you take. Keep a list to show your doctor and pharmacist when you get a new medicine.