How to Take ORKAMBI®

Watch a video to learn about how to take ORKAMBI. You can also read about this topic below.

The recommended dose of ORKAMBI is 2 tablets every 12 hours. Your dose may be different. Your healthcare provider will tell you how much ORKAMBI to take and when to take it.

Continue to take all of your other prescribed cystic fibrosis (CF) therapies as directed by your healthcare provider.

Always take ORKAMBI with fat-containing food.

The importance of taking ORKAMBI with fat-containing foods

ORKAMBI should always be taken with fat-containing foods because the fat helps your body better absorb the medicine. You can take ORKAMBI right before, during, or right after your meal or snack.

Examples of fat-containing foods you can take with ORKAMBI include eggs, avocados, nuts, butter, peanut butter, cheese pizza, and whole-milk dairy products (such as whole milk, cheese, and yogurt).


How ORKAMBI is packaged

For people age 12 and olderTablet Strips
For children age 6 through 11 Tablet Strips
Not actual size

Fitting ORKAMBI into your daily routine

In the morning: remove 2 ORKAMBI tablets from the blister strip (do not push tablet through backing) and take them with a fat-containing breakfast food like eggs or a bagel with cream cheese.

In the evening: 12 hours later, remove 2 ORKAMBI tablets from the blister strip (do not push tablet through backing) and take them with fat-containing dinner food like salmon or cheese pizza, or a fat-containing dessert like ice cream or peanut butter balls.

If you take ORKAMBI at times other than breakfast and dinner time, you may take it with a snack that contains fat. Some options for fat-containing snacks include whole-milk string cheese and trail mix with nuts.

What to do if you miss a dose

  • If you miss a dose within 6 hours of when you usually take it, take your dose with fat-containing food as soon as possible
  • If you miss a dose, and it is more than 6 hours after the time you usually take it, skip that dose only and take your next dose when you usually take it. Do not take 2 doses at the same time to make up for your missed dose
  • Tell your doctor if you stop ORKAMBI for more than 1 week. Your doctor may need to change your dose of ORKAMBI or other medicines you take

Keep ORKAMBI and all medicines out of the reach of children.